Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30330007 | 1.00 | NPC1 (0.32) | NPC1RAB9AKCNH2KMT2ASMN1; SMN2 | |
| SCHEMBL30330211 | 0.92 | ABCB1 (0.36) | KMT2ASMN1; SMN2MAPTABCB1ABCC1 | |
| SCHEMBL30329678 | 0.92 | ABCB1 (0.36) | KMT2ASMN1; SMN2MAPTABCB1ABCC1 | |
| SCHEMBL30329819 | 0.86 | EHMT2 (0.37) | KCNH2EPHB4KDM4E | |
| SCHEMBL31107984 | 0.86 | EHMT2 (0.37) | KCNH2EPHB4KDM4E | |
| SCHEMBL30329966 | 0.78 | EHMT2 (0.37) | ABCB1ABCC1ABCG2 | |
| SCHEMBL31108019 | 0.78 | EHMT2 (0.37) | ABCB1ABCC1ABCG2 | |
| SCHEMBL25166694 | 0.77 | EPHB4 (0.35) | NPC1RAB9AKCNH2KMT2ASMN1; SMN2 | |
| SCHEMBL30330226 | 0.77 | EPHB4 (0.35) | NPC1RAB9AKCNH2KMT2ASMN1; SMN2 | |
| SCHEMBL25166455 | 0.75 | NPC1 (0.38) | NPC1RAB9AKCNH2KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118647610-A | Novel modulators of EHMT1 and EHMT2 and therapeutic uses thereof | 探戈医药股份有限公司 | 2024-09-13 | — | — | CN | disclosed |
| EP-4416143-A1 | NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF | Tango Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064586-A1 | NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF | TANGO THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |