Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 6/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.36 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.36 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.36 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23537868 | 1.00 | HTRA1 (0.40) | HTRA1ALDH1A1LMNAKMT2AMMP1 | |
| SCHEMBL25168230 | 1.00 | HTRA1 (0.40) | HTRA1ALDH1A1LMNAKMT2AMMP1 | |
| SCHEMBL25495877 | 1.00 | HTRA1 (0.40) | HTRA1ALDH1A1LMNAKMT2AMMP1 | |
| SCHEMBL25168229 | 1.00 | HTRA1 (0.40) | HTRA1ALDH1A1LMNAKMT2AMMP1 | |
| SCHEMBL25495881 | 0.94 | HTRA1 (0.40) | HTRA1ALDH1A1LMNAKMT2AMMP1 | |
| SCHEMBL25444832 | 0.93 | HTRA1 (0.44) | HTRA1ALDH1A1LMNAKMT2AMMP1 | |
| SCHEMBL25171447 | 0.92 | PSMB10 (0.42) | HTRA1ALDH1A1LMNAKMT2AMMP1 | |
| SCHEMBL25171446 | 0.92 | PSMB10 (0.42) | HTRA1ALDH1A1LMNAKMT2AMMP1 | |
| SCHEMBL25171448 | 0.92 | PSMB10 (0.42) | HTRA1ALDH1A1LMNAKMT2AMMP1 | |
| SCHEMBL25500045 | 0.91 | MMP1 (0.40) | MMP1PSMB8PSMB5PSMA1PSMB9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12577259-B2 | PCSK9 antagonist compounds | MERCK SHARP & DOHME LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-20230144324-A1 | PCSK9 ANTAGONIST COMPOUNDS | MERCK SHARP & DOHME LLC | 2023-05-11 | — | — | US | disclosed |
| EP-4076492-A1 | PCSK9 ANTAGONIST COMPOUNDS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12577259-B2 | PCSK9 antagonist compounds | PCSK9, LDLR, PCSK6 | HTRA1 735/4885ALDH1A1 4460/4885LMNA 395/4885 |
| US-20230144324-A1 | PCSK9 ANTAGONIST COMPOUNDS | PCSK9, PCSK7, PCSK6 | HTRA1 103/4885ALDH1A1 2378/4885LMNA 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.