Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545981 | 0.88 | ERBB2 (0.56) | EGFRERBB2KCNH2 | |
| SCHEMBL2542968 | 0.87 | EGFR (0.71) | EGFRERBB2KCNH2 | |
| SCHEMBL2535974 | 0.87 | EGFR (0.71) | EGFRERBB2KCNH2 | |
| SCHEMBL2520501 | 0.86 | ERBB2 (0.57) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL2520799 | 0.86 | ERBB2 (0.57) | EGFRERBB2KCNH2ERBB3ERBB4 | |
| SCHEMBL5518435 | 0.86 | EGFR (0.71) | EGFRERBB2KCNH2ERBB3ERBB4 | |
| SCHEMBL5520007 | 0.85 | EGFR (0.65) | EGFRERBB2KCNH2 | |
| SCHEMBL2544657 | 0.84 | ERBB2 (0.62) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL5517462 | 0.84 | ERBB2 (0.72) | EGFRERBB2KCNH2 | |
| SCHEMBL2544330 | 0.84 | ERBB2 (0.69) | EGFRERBB2KCNH2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838712-B8 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2011-10-12 | — | — | EP | disclosed |
| EP-1838712-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006064196-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |