Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 20/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2514925 | 0.84 | GRM5 (0.34) | TLR7 | |
| SCHEMBL1773748 | 0.81 | TLR7 (0.42) | TLR7TLR8NUDT1 | |
| SCHEMBL2513479 | 0.80 | TLR7 (0.43) | TLR7TLR8NUDT1 | |
| SCHEMBL2511885 | 0.80 | TLR7 (0.39) | TLR7TLR8 | |
| SCHEMBL2513067 | 0.80 | TLR7 (0.42) | TLR7TLR8NUDT1 | |
| SCHEMBL2512590 | 0.80 | TLR7 (0.43) | TLR7TLR8NUDT1 | |
| SCHEMBL1775037 | 0.79 | TLR7 (0.43) | TLR7TLR8 | |
| SCHEMBL2511886 | 0.79 | TLR7 (0.41) | TLR7TLR8NUDT1 | |
| SCHEMBL1774252 | 0.78 | TLR7 (0.45) | TLR7TLR8 | |
| SCHEMBL10237194 | 0.78 | TLR7 (0.45) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034938-B2 | Imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a CH( R1) group in the fused ring at 1-position of imidazo ring; modulate immune response, by induction of cytokine biosynthesis or other mechanism | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2011-10-11 | — | — | US | disclosed |