Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.67 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30576518 | 1.00 | MTNR1A (0.67) | MTNR1AMTNR1BEPHX2KMT2AL3MBTL1 | |
| SCHEMBL25331508 | 0.92 | MTNR1A (0.57) | MTNR1AMTNR1BEPHX2KMT2AL3MBTL1 | |
| SCHEMBL30576537 | 0.92 | MTNR1A (0.57) | MTNR1AMTNR1BEPHX2KMT2AL3MBTL1 | |
| SCHEMBL27057538 | 0.91 | MTNR1A (0.56) | MTNR1AMTNR1BEPHX2KMT2AL3MBTL1 | |
| SCHEMBL27057488 | 0.89 | MTNR1A (0.54) | MTNR1AMTNR1BEPHX2KMT2AL3MBTL1 | |
| SCHEMBL27057522 | 0.89 | MTNR1A (0.54) | MTNR1AMTNR1BEPHX2KMT2AL3MBTL1 | |
| SCHEMBL27057532 | 0.89 | MTNR1A (0.54) | MTNR1AMTNR1BEPHX2KMT2AL3MBTL1 | |
| SCHEMBL25330555 | 0.89 | MTNR1A (0.54) | MTNR1AMTNR1BEPHX2KMT2AL3MBTL1 | |
| SCHEMBL30767980 | 0.88 | MTNR1A (0.53) | MTNR1AMTNR1BEPHX2KMT2AL3MBTL1 | |
| SCHEMBL30576466 | 0.86 | SLC6A2 (0.65) | MTNR1AMTNR1BEPHX2KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116783165-A | 1,2,3, 4-tetrahydroquinoline derivatives as YAP/TAZ-TEAD activation inhibitors for the treatment of cancer | 天主教鲁汶大学 | 2023-09-19 | — | — | CN | disclosed |
| US-8273754-B2 | Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds | ARQULE, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-8273754-B2 | Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds | ARQULE, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| EP-2379556-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078430-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010078430-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100172867-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| US-20100172867-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100172867-A1 | SUBSTITUTED 1H-PYRAZOLO[3,4-D]PYRIMIDINE-6-AMINE COMPOUNDS | DPYD, MKI67, TYMP | MTNR1A 1366/4885MTNR1B 921/4885EPHX2 1854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.