Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CBLB | Q13191 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30891999 | 1.00 | HTR1A (0.36) | HTR1AHTR2CALDH1A1HSP90AB1KMT2A | |
| SCHEMBL25186525 | 0.86 | HTR1A (0.40) | HTR1AHTR2CALDH1A1KMT2AMEN1 | |
| SCHEMBL31275071 | 0.86 | HTR1A (0.34) | HTR1AHTR2CALDH1A1KMT2AKDM4E | |
| SCHEMBL31275006 | 0.85 | HTR2C (0.34) | HTR1AHTR2CALDH1A1CBLB | |
| SCHEMBL31274790 | 0.81 | MAOB (0.45) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL25182795 | 0.79 | HTR1A (0.37) | HTR1AHTR2CALDH1A1KMT2AMEN1 | |
| SCHEMBL25180165 | 0.79 | HTR1A (0.37) | HTR1AHTR2CALDH1A1KMT2AMEN1 | |
| SCHEMBL30374541 | 0.79 | HTR1A (0.37) | HTR1AHTR2CALDH1A1KMT2AMEN1 | |
| SCHEMBL30374388 | 0.79 | HTR1A (0.37) | HTR1AHTR2CALDH1A1KMT2AMEN1 | |
| SCHEMBL25186409 | 0.75 | HTR1A (0.43) | HTR1AHTR2CMAPK1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12187709-B2 | Lactams as CBL-B inhibitors selective over C-CBL | GENENTECH, INC. (US) | 2025-01-07 | — | — | US | disclosed |
| EP-4426691-A1 | LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL | Genentech, Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| US-20230212153-A1 | LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL | GENENTECH, INC. (US) | 2023-07-06 | — | — | US | disclosed |
| WO-2023081853-A1 | LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL | GENENTECH, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212153-A1 | LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL | CBL, CBLB, CBLC | HTR1A 4122/4885HTR2C 4036/4885ALDH1A1 3554/4885 |
| US-12187709-B2 | Lactams as CBL-B inhibitors selective over C-CBL | CBL, CBLB, CBLC | HTR1A 4122/4885HTR2C 4036/4885ALDH1A1 3554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.