Sugi Predict

Sugi Predict / Compounds / SCHEMBL251878

SCHEMBL251878

SCHEMBL251878

CN(N)C(=O)Nc1ccccc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 2/20 0.56
▸ HSD17B10 Q99714 2/20 0.54
▸ NAPRT Q6XQN6 1/20 0.54
▸ KMT2A Q03164 2/20 0.53
▸ MEN1 O00255 1/20 0.53
▸ ATM Q13315 1/20 0.53
▸ SMN1; SMN2 Q16637 2/20 0.52
▸ TP53 P04637 2/20 0.52
▸ EPHX1 P07099 1/20 0.52
▸ TSHR P16473 1/20 0.52
▸ EPHX2 P34913 1/20 0.52
▸ CDK9 P50750 1/20 0.52
▸ CLK4 Q9HAZ1 1/20 0.52
▸ ALDH1A1 P00352 2/20 0.52
▸ NPSR1 Q6W5P4 1/20 0.52
▸ MAPT P10636 3/20 0.47
▸ NPC1 O15118 2/20 0.47
▸ RAB9A P51151 2/20 0.47
▸ ALOX15 P16050 1/20 0.47
▸ SCN1A P35498 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6206532 0.83 SMN1; SMN2 (0.56) MTORHSD17B10NAPRTKMT2AMEN1
Fenuron SCHEMBL62004 0.83 TSHR (0.64) MTORHSD17B10NAPRTKMT2AMEN1
Fenuron SCHEMBL9451054 0.83 TSHR (0.64) MTORHSD17B10NAPRTKMT2AMEN1
Fenuron SCHEMBL8366971 0.83 TSHR (0.64) MTORHSD17B10NAPRTKMT2AMEN1
Fenuron SCHEMBL10806698 0.83 TSHR (0.64) MTORHSD17B10NAPRTKMT2AMEN1
Fenuron SCHEMBL28146684 0.82 TSHR (0.58) MTORHSD17B10NAPRTKMT2AMEN1
SCHEMBL7613102 0.81 MTOR (0.58) MTORHSD17B10NAPRTKMT2AMEN1
SCHEMBL23168327 0.79 MTOR (0.56) MTORHSD17B10NAPRTKMT2AMEN1
SCHEMBL11286984 0.79 MTOR (0.56) MTORHSD17B10NAPRTKMT2AMEN1
SCHEMBL9337457 0.79 MTOR (0.56) MTORHSD17B10NAPRTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110236326-A1 Skin Whitener COGNIS IP MANAGEMENT GMBH (DE) 2011-09-29 — — US claimed
EP-0323590-A2 Carbazoyl derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1989-07-12 — — EP claimed
CN-105198861-B 6- acyl group -1,2,4- triazine -3,5- derovatives and herbicide FMC公司 2019-11-22 — — CN disclosed
US-20190047968-A1 6-ACYL-1,2,4-TRIAZINE-3,5-DIONE DERIVATIVE AND HERBICIDES FMC CORP (US) 2019-02-14 — — US disclosed
US-10081608-B2 6-acyl-1,2,4-triazine-3,5-dione derivative and herbicides FMC CORPORATION (US) 2018-09-25 — — US disclosed
CN-104370801-B Carbazole compound and application thereof 东曹株式会社 2017-11-03 — — CN disclosed
US-9650565-B2 Carbazole compound and use thereof TOSOH CORPORATION (JP) 2017-05-16 — — US disclosed
US-20170129861-A1 6-ACYL-1,2,4-TRIAZINE-3,5-DIONE DERIVATIVE AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2017-05-11 — — US disclosed
CN-104326968-B Carbazole compound and use thereof 东曹株式会社 2017-04-12 — — CN disclosed
US-9573909-B2 6-acyl-1,2,4-triazine-3,5-dione derivative and herbicides FMC CORPORATION (US) 2017-02-21 — — US disclosed
EP-3020709-A1 6-ACYL-1,2,4-TRIAZINE-3,5-DIONE DERIVATIVE AND HERBICIDES FMC CORPORATION (US) 2016-05-18 — — EP disclosed
EP-2193779-A1 Skin whitener Cognis IP Management GmbH (DE) 2010-06-09 — — EP disclosed
US-5098462-A Herbicides SANDOZ LTD. (CH) 1992-03-24 — — US disclosed
US-5098466-A Herbicides SANDOZ LTD. (CH) 1992-03-24 — — US disclosed
EP-0126088-A1 ARYL SUBSTITUTED 7-OXABICYCLOHEPTANE COMPOUNDS E.R. SQUIBB & SONS, INC. (US) 1984-11-28 — — EP disclosed
US-4463015-A Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation E. R. SQUIBB & SONS, INC. (US) 1984-07-31 — — US disclosed
WO-1984000754-A1 ARYL SUBSTITUTED 7-OXABICYCLOHEPTANE COMPOUNDS SQUIBB & SONS INC (US) 1984-03-01 — — WO disclosed
US-4418076-A 7-Oxabicycloheptane hydrazone prostaglandin analogs useful in treating thrombolytic diseases E. R. SQUIBB & SONS, INC. (US) 1983-11-29 — — US disclosed
US-4339382-A Process for manufacturing N-arylthiocarbamoyl-2-amino-1H-isoindole-1,3-(2H)diones GULF OIL CORPORATION (US) 1982-07-13 — — US disclosed
EP-0016571-A1 N-(Arylthiocarbamoyl)-2-amino-1H-isoindole-1,3-(2H)diones, processes for their preparation and their use as plant growth regulators Gulf Oil Corporation (US) 1980-10-01 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110236326-A1 Skin Whitener TYR, MC1R, H1-5 MTOR 3790/4885HSD17B10 1331/4885NAPRT 3002/4885
US-10081608-B2 6-acyl-1,2,4-triazine-3,5-dione derivative and herbicides DDT, AADAC, DAZAP1 MTOR 4774/4885HSD17B10 230/4885NAPRT 3401/4885
US-20170129861-A1 6-ACYL-1,2,4-TRIAZINE-3,5-DIONE DERIVATIVE AND HERBICIDES DDT, AADAC, DAZAP1 MTOR 4774/4885HSD17B10 230/4885NAPRT 3401/4885
US-20190047968-A1 6-ACYL-1,2,4-TRIAZINE-3,5-DIONE DERIVATIVE AND HERBICIDES DDT, AADAC, DAZAP1 MTOR 4774/4885HSD17B10 230/4885NAPRT 3401/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.