SCHEMBL6206532

SCHEMBL6206532

NN(N)C(=O)Nc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.56
TP53 P04637 2/20 0.56
TSHR P16473 2/20 0.56
EPHX1 P07099 1/20 0.56
EPHX2 P34913 1/20 0.56
CDK9 P50750 1/20 0.56
CLK4 Q9HAZ1 1/20 0.56
ALDH1A1 P00352 3/20 0.55
NPSR1 Q6W5P4 1/20 0.55
HSD17B10 Q99714 3/20 0.52
NAPRT Q6XQN6 1/20 0.52
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
MAPT P10636 2/20 0.50
MTOR P42345 2/20 0.50
GAA P10253 1/20 0.50
GFER P55789 1/20 0.50
NPC1 O15118 1/20 0.50
ALOX15 P16050 1/20 0.50
RAB9A P51151 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL251878 0.83 MTOR (0.56) SMN1; SMN2TP53TSHREPHX1EPHX2
SCHEMBL28067546 0.82 MEN1 (0.49) SMN1; SMN2TP53TSHREPHX1EPHX2
SCHEMBL11726723 0.81 MEN1 (0.56) SMN1; SMN2TP53TSHREPHX1EPHX2
SCHEMBL28431265 0.78 TDP1 (0.57) SMN1; SMN2ALDH1A1MAPTNPC1RAB9A
SCHEMBL27547152 0.78 ALDH1A1 (0.51) SMN1; SMN2TP53TSHREPHX1EPHX2
SCHEMBL28025690 0.78 MTOR (0.56) SMN1; SMN2TP53TSHREPHX1EPHX2
SCHEMBL11617578 0.78 MEN1 (0.62) SMN1; SMN2TP53TSHREPHX1EPHX2
Fenuron SCHEMBL9451054 0.77 TSHR (0.64) TSHRHSD17B10NAPRTMEN1KMT2A
Fenuron SCHEMBL62004 0.77 TSHR (0.64) TSHRHSD17B10NAPRTMEN1KMT2A
SCHEMBL9518721 0.77 SMN1; SMN2 (0.56) SMN1; SMN2TP53TSHREPHX1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047672-B1 PROCESS FOR PREPARING SPARINGLY SOLUBLE AROMATIC AMINES CIBA SC HOLDING AG (CH) 2005-06-22 EP disclosed
EP-1047672-A1 PROCESS FOR PREPARING SPARINGLY SOLUBLE AROMATIC AMINES Ciba SC Holding AG (CH) 2000-11-02 EP disclosed
US-6087480-A Process for preparing sparingly soluble aromatic amines CIBA SPECIALTY CHEMCALS CORPORATION (US) 2000-07-11 US disclosed
WO-1999036402-A1 PROCESS FOR PREPARING SPARINGLY SOLUBLE AROMATIC AMINES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1999-07-22 WO disclosed
EP-0012983-B1 DIAMINOPHENYL UREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE PREPARATION OF AMINOBENZIMIDAZOLONES-(2) HOECHST AKTIENGESELLSCHAFT (DE) 1982-03-31 EP disclosed
EP-0012983-A1 Diaminophenyl ureas, process for their preparation and their use in the preparation of aminobenzimidazolones-(2) HOECHST AKTIENGESELLSCHAFT (DE) 1980-07-09 EP disclosed