SCHEMBL25191007

SCHEMBL25191007

COc1ccc(/C=C/C(=O)c2ccc(Br)cc2O)cc1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.80
ABCG2 Q9UNQ0 5/20 0.80
MEN1 O00255 5/20 0.80
KMT2A Q03164 5/20 0.80
LMNA P02545 4/20 0.80
SMN1; SMN2 Q16637 4/20 0.80
MAPK1 P28482 3/20 0.80
APP P05067 3/20 0.80
CYP3A4 P08684 2/20 0.80
CYP2C19 P33261 2/20 0.80
ALDH1A1 P00352 4/20 0.76
HPGD P15428 2/20 0.76
ALOX15 P16050 2/20 0.76
HSD17B10 Q99714 2/20 0.76
TP53 P04637 1/20 0.76
KDM4E B2RXH2 3/20 0.71
TDP1 Q9NUW8 2/20 0.71
POLB P06746 2/20 0.71
HSP90AA1 P07900 1/20 0.71
MAOB P27338 5/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25265052 1.00 MAPT (0.80) MAPTABCG2MEN1KMT2ALMNA
SCHEMBL30383556 1.00 MAPT (0.80) MAPTABCG2MEN1KMT2ALMNA
SCHEMBL30383705 0.92 ABCG2 (0.84) MAPTABCG2MEN1KMT2ALMNA
SCHEMBL2129845 0.92 ABCG2 (0.84) MAPTABCG2MEN1KMT2ALMNA
SCHEMBL2129839 0.92 ABCG2 (0.84) MAPTABCG2MEN1KMT2ALMNA
SCHEMBL5088006 0.89 MAPT (0.76) MAPTABCG2MEN1KMT2ALMNA
SCHEMBL5087997 0.89 MAPT (0.76) MAPTABCG2MEN1KMT2ALMNA
SCHEMBL25189208 0.89 ABCG2 (1.00) MAPTABCG2MEN1KMT2ALMNA
SCHEMBL634187 0.89 ABCG2 (1.00) MAPTABCG2MEN1KMT2ALMNA
SCHEMBL30384538 0.89 ABCG2 (1.00) MAPTABCG2MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAPT 3297/4885ABCG2 1606/4885MEN1 3367/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885ABCG2 3622/4885MEN1 2457/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885ABCG2 3622/4885MEN1 2457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.