SCHEMBL25192256

SCHEMBL25192256

COc1cc(O)c(C(=O)C=Cc2ccc(OC)c(OCc3ccccc3)c2)c(OC)c1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 4/20 0.76
MAPT P10636 5/20 0.70
KMT2A Q03164 4/20 0.70
CYP3A4 P08684 4/20 0.70
TP53 P04637 2/20 0.70
ATM Q13315 1/20 0.70
HSD17B10 Q99714 1/20 0.70
MEN1 O00255 3/20 0.69
KDM4E B2RXH2 2/20 0.69
HPGD P15428 2/20 0.69
TDP1 Q9NUW8 2/20 0.69
MCL1 Q07820 1/20 0.69
USP2 O75604 1/20 0.69
ALDH1A1 P00352 1/20 0.69
ALOX15 P16050 1/20 0.69
MAPK1 P28482 1/20 0.69
PDE4A P27815 1/20 0.67
PDE4B Q07343 1/20 0.67
PDE4C Q08493 1/20 0.67
PDE4D Q08499 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30384422 1.00 ABCG2 (0.76) ABCG2MAPTKMT2ACYP3A4TP53
SCHEMBL25193887 1.00 ABCG2 (0.76) ABCG2MAPTKMT2ACYP3A4TP53
SCHEMBL30383596 0.96 ABCG2 (0.76) ABCG2MAPTKMT2ACYP3A4TP53
SCHEMBL5433415 0.96 ABCG2 (0.76) ABCG2MAPTKMT2ACYP3A4TP53
SCHEMBL5433412 0.96 ABCG2 (0.76) ABCG2MAPTKMT2ACYP3A4TP53
SCHEMBL30383193 0.93 ABCG2 (0.73) ABCG2MAPTKMT2ACYP3A4TP53
SCHEMBL25216240 0.93 ABCG2 (0.73) ABCG2MAPTKMT2ACYP3A4TP53
SCHEMBL30384698 0.93 ABCG2 (0.73) ABCG2MAPTKMT2ACYP3A4TP53
SCHEMBL14178910 0.93 ABCG2 (0.73) ABCG2MAPTKMT2ACYP3A4TP53
SCHEMBL19183186 0.90 PDE4A (0.70) ABCG2MAPTKMT2ACYP3A4TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B ABCG2 1606/4885MAPT 3297/4885KMT2A 2792/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 ABCG2 3622/4885MAPT 3512/4885KMT2A 3188/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 ABCG2 3622/4885MAPT 3512/4885KMT2A 3188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.