SCHEMBL25194331

SCHEMBL25194331

COc1ccc(C=CC(=O)c2ccc(OC[C@](O)(Cn3cncn3)c3ccc(F)cc3F)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.56
CYP2C9 P11712 4/20 0.56
CYP2C19 P33261 4/20 0.56
LMNA P02545 3/20 0.56
HSP90AA1 P07900 1/20 0.56
CYP19A1 P11511 1/20 0.56
CYP11B1 P15538 1/20 0.56
CYP11B2 P19099 1/20 0.56
ADRA1A P35348 1/20 0.56
CYP51A1 Q16850 1/20 0.56
HDAC3 O15379 1/20 0.49
HDAC4 P56524 1/20 0.49
HDAC1 Q13547 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC10 Q969S8 1/20 0.49
HDAC11 Q96DB2 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
HDAC9 Q9UKV0 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30383587 1.00 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL15380530 1.00 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL30383637 1.00 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL30383430 1.00 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL18166806 1.00 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL25239612 1.00 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL15380179 1.00 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL15380795 1.00 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL15383637 1.00 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL30384108 1.00 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B CYP3A4 928/4885CYP2C9 124/4885CYP2C19 109/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 CYP3A4 1589/4885CYP2C9 1237/4885CYP2C19 583/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 CYP3A4 1589/4885CYP2C9 1237/4885CYP2C19 583/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.