Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15674757 | 0.80 | PLAU (0.42) | PLAUDYRK1AALDH1A1KDM4ELMNA | |
| SCHEMBL29989503 | 0.77 | PLAU (0.40) | PLAUALDH1A1METKDM4ELMNA | |
| SCHEMBL16654525 | 0.77 | PLAU (0.40) | PLAUALDH1A1METKDM4ELMNA | |
| SCHEMBL29268175 | 0.77 | PLAU (0.40) | PLAUALDH1A1METKDM4ELMNA | |
| SCHEMBL21994706 | 0.77 | PLAU (0.40) | PLAUALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL19189346 | 0.75 | PLAU (0.32) | PLAUALDH1A1ATML3MBTL1 | |
| SCHEMBL16552187 | 0.72 | PLAU (0.40) | PLAUALDH1A1 | |
| SCHEMBL16540711 | 0.72 | PLAU (0.40) | PLAU | |
| SCHEMBL18335087 | 0.72 | PLAU (0.37) | PLAUALDH1A1MAPTL3MBTL1 | |
| SCHEMBL21718921 | 0.72 | PLAU (0.42) | PLAUDYRK1AALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022164789-A9 | TRICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISORDERS | SCHRÖDINGER, INC. (US) | 2023-05-25 | — | — | WO | disclosed |