Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.68 |
| ▸ | MEN1 | O00255 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30500273 | 1.00 | KMT2A (0.68) | KMT2AMEN1RAB9ANPC1PTPN2 | |
| SCHEMBL30527206 | 0.84 | KMT2A (0.48) | KMT2AMEN1RAB9ANPC1HPGD | |
| SCHEMBL25416860 | 0.84 | KMT2A (0.48) | KMT2AMEN1RAB9ANPC1HPGD | |
| SCHEMBL13789283 | 0.81 | KMT2A (1.00) | KMT2AMEN1RAB9ANPC1PTPN2 | |
| SCHEMBL25416599 | 0.81 | HPGD (0.53) | KMT2AMEN1RAB9ANPC1HSD17B10 | |
| SCHEMBL30527198 | 0.81 | HPGD (0.53) | KMT2AMEN1RAB9ANPC1HSD17B10 | |
| SCHEMBL25415524 | 0.79 | HSD17B13 (0.53) | KMT2AMEN1RAB9ANPC1HPGD | |
| SCHEMBL30527194 | 0.79 | HSD17B13 (0.53) | KMT2AMEN1RAB9ANPC1HPGD | |
| SCHEMBL25414179 | 0.79 | KMT2A (0.44) | KMT2AMEN1RAB9ANPC1HPGD | |
| SCHEMBL25415796 | 0.79 | KMT2A (0.44) | KMT2AMEN1RAB9ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2023-09-07 | — | — | US | disclosed |
| CN-116323578-A | Thiophene HSD17B13 inhibitor and application thereof | 伊尼制药公司 | 2023-06-23 | — | — | CN | disclosed |
| EP-4185381-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | Inipharm, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | HSD17B3, HSD17B1, HSD17B13 | KMT2A 4053/4885MEN1 4723/4885RAB9A 4191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.