Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NEK2 | P51955 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25184918 | 0.82 | KDM4E (0.43) | KDM4ELMNAJAK2JAK1TYK2 | |
| SCHEMBL30441471 | 0.82 | KDM4E (0.43) | KDM4ELMNAJAK2JAK1TYK2 | |
| SCHEMBL17977039 | 0.80 | SMO (0.43) | KDM4ECYP2C19LMNAHTTSMN1; SMN2 | |
| SCHEMBL20520106 | 0.79 | TRPV1 (0.44) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL20524392 | 0.79 | TRPV1 (0.44) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL21768430 | 0.77 | SMO (0.54) | HSD17B10L3MBTL1GAA | |
| SCHEMBL20640242 | 0.77 | CNR2 (0.41) | KDM4EHSD17B10HPGDCYP2C19JAK2 | |
| SCHEMBL18149848 | 0.77 | KDM4E (0.51) | KDM4EHSD17B10USP2HPGDNPSR1 | |
| SCHEMBL22491884 | 0.76 | NOTUM (0.49) | KDM4ECYP2C19NOTUM | |
| SCHEMBL22655487 | 0.76 | NOTUM (0.49) | KDM4ECYP2C19NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |