Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 11/20 | 0.43 |
| ▸ | CA1 | P00915 | 11/20 | 0.43 |
| ▸ | CA2 | P00918 | 11/20 | 0.43 |
| ▸ | CA4 | P22748 | 11/20 | 0.43 |
| ▸ | CA7 | P43166 | 11/20 | 0.43 |
| ▸ | CA9 | Q16790 | 11/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20524392 | 1.00 | TRPV1 (0.44) | TRPV1TRPM8CA12CA1CA2 | |
| SCHEMBL20520072 | 0.85 | SUV39H2 (0.51) | JAK3 | |
| SCHEMBL15206576 | 0.80 | TRPV1 (0.50) | TRPV1TRPM8CA12CA1CA2 | |
| SCHEMBL15205294 | 0.80 | TRPV1 (0.50) | TRPV1TRPM8CA12CA1CA2 | |
| SCHEMBL997974 | 0.80 | TRPV1 (0.50) | TRPV1TRPM8CA12CA1CA2 | |
| SCHEMBL25200345 | 0.79 | KDM4E (0.50) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL20520145 | 0.78 | USP30 (0.39) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4278748 | 0.77 | GPBAR1 (0.47) | CA12CA1CA2CA4CA7 | |
| SCHEMBL20445994 | 0.77 | SMPD3 (0.42) | TRPV1CA12CA1CA2CA4 | |
| SCHEMBL28364264 | 0.76 | JAK2 (0.40) | SMOJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601284-B1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | HOFFMANN LA ROCHE (CH) | 2023-12-27 | — | — | EP | disclosed |
| US-11034692-B1 | Naphthyridines as inhibitors of HPK1 | GENENTECH, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| EP-3601284-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | H. Hoffnabb-La Roche Ag (CH) | 2020-02-05 | — | — | EP | disclosed |
| US-10407424-B2 | Naphthyridines as inhibitors of HPK1 | GENENTECH, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-20180282328-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | US | disclosed |
| WO-2018183956-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407424-B2 | Naphthyridines as inhibitors of HPK1 | NEK1, NEK5, NEK11 | TRPV1 4749/4885TRPM8 4564/4885CA12 4882/4885 |
| US-20180282328-A1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | NEK1, NEK5, NEK11 | TRPV1 4749/4885TRPM8 4564/4885CA12 4882/4885 |
| US-11034692-B1 | Naphthyridines as inhibitors of HPK1 | NEK1, NEK5, NEK11 | TRPV1 4749/4885TRPM8 4564/4885CA12 4882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.