Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 7/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742415 | 1.00 | HTR2B (0.61) | HTR2BPOLBKDM4EMAPK1USP30 | |
| SCHEMBL2514536 | 1.00 | HTR2B (0.61) | HTR2BPOLBKDM4EMAPK1USP30 | |
| SCHEMBL739141 | 0.89 | HTR2B (0.71) | HTR2BPOLBKDM4E | |
| SCHEMBL741494 | 0.86 | KDM4E (0.65) | HTR2BPOLBKDM4EMAPK1USP30 | |
| SCHEMBL13853671 | 0.85 | POLB (0.62) | HTR2BPOLBKDM4EMAPK1USP30 | |
| SCHEMBL4121296 | 0.85 | HTR2B (0.72) | HTR2BSMN1; SMN2 | |
| SCHEMBL1299373 | 0.85 | HTR2B (0.83) | HTR2BPOLBKDM4E | |
| SCHEMBL1299672 | 0.85 | HTR2B (0.83) | HTR2BPOLBKDM4E | |
| SCHEMBL1298694 | 0.85 | HTR2B (0.83) | HTR2BPOLBKDM4E | |
| SCHEMBL741139 | 0.84 | POLB (0.61) | HTR2BPOLBKDM4EMAPK1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379524-A1 | SEROTONIN 5-HT2B RECEPTOR INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010080357-A1 | SEROTONIN 5-HT2B RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-15 | — | — | WO | disclosed |