Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.56 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | CDC42 | P60953 | 1/20 | 0.41 |
| ▸ | RAC1 | P63000 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27125871 | 1.00 | HTR2C (0.56) | HTR2CMTNR1AMTNR1BPRMT5ITGB3 | |
| Fumaric Acid SCHEMBL30729586 | 1.00 | HTR2C (0.56) | HTR2CMTNR1AMTNR1BPRMT5ITGB3 | |
| SCHEMBL23927896 | 0.89 | HTR2C (0.69) | HTR2CMTNR1AMTNR1BPRMT5HDAC11 | |
| SCHEMBL29780341 | 0.89 | HTR2C (0.69) | HTR2CMTNR1AMTNR1BPRMT5HDAC11 | |
| SCHEMBL23927895 | 0.89 | HTR2C (0.69) | HTR2CMTNR1AMTNR1BPRMT5HDAC11 | |
| SCHEMBL23956071 | 0.89 | HTR2C (0.69) | HTR2CMTNR1AMTNR1BPRMT5HDAC11 | |
| Fumaric Acid SCHEMBL29435350 | 0.85 | HTR2C (0.55) | HTR2CPRMT5HDAC8HDAC6FABP4 | |
| SCHEMBL30839304 | 0.82 | HTR2C (0.57) | HTR2CMTNR1AMTNR1BPRMT5ITGB3 | |
| SCHEMBL29162318 | 0.82 | HTR2C (0.57) | HTR2CMTNR1AMTNR1BPRMT5ITGB3 | |
| SCHEMBL29162320 | 0.82 | HTR2C (0.57) | HTR2CMTNR1AMTNR1BPRMT5ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12435036-B2 | Salts and solid forms of (R)-1-(5-methoxy-1H-indol-1-yl)-n,n-dimethylpropan-2-amine | TERRAN BIOSCIENCES INC. (US) | 2025-10-07 | — | — | US | disclosed |
| US-12319652-B2 | Salts and solid forms of (R)-1-(5-methoxy-1H-indol-1-yl)-N,N-dimethylpropan-2-amine | TERRAN BIOSCIENCES INC. (US) | 2025-06-03 | — | — | US | disclosed |
| US-20250002456-A1 | SALTS AND SOLID FORMS OF (R)-1-(5-METHOXY-1H-INDOL-1-YL)-N,N-DIMETHYLPROPAN-2-AMINE | TERRAN BIOSCIENCES INC. | 2025-01-02 | — | — | US | disclosed |
| US-20240034718-A1 | SALTS AND SOLID FORMS OF (R)-1-(5-METHOXY-1H-INDOL-1-YL)-N,N-DIMETHYLPROPAN-2-AMINE | TERRAN BIOSCIENCES INC. | 2024-02-01 | — | — | US | disclosed |
| US-20240002337-A1 | SALTS AND SOLID FORMS OF (R)-1-(5-METHOXY-1H-INDOL-1-YL)-N,N-DIMETHYLPROPAN-2-AMINE | TERRAN BIOSCIENCES INC (US) | 2024-01-04 | — | — | US | disclosed |
| WO-2023091974-A2 | SALT AND SOLID FORMS OF (R)-1-(5-METHOXY-1 H-INDOL-1-YL)-N,N-DIMETHYLPROPAN-2-AMINE | TERRAN BIOSCIENCES, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12435036-B2 | Salts and solid forms of (R)-1-(5-methoxy-1H-indol-1-yl)-n,n-dimethylpropan-2-amine | SLC6A4, GRIN2D, SLC1A2 | HTR2C 10/4885HTR2A 13/4885SLC6A2 6/4885 |
| US-20240002337-A1 | SALTS AND SOLID FORMS OF (R)-1-(5-METHOXY-1H-INDOL-1-YL)-N,N-DIMETHYLPROPAN-2-AMINE | SLC6A4, GRIN2D, SLC1A2 | HTR2C 10/4885HTR2A 13/4885SLC6A2 6/4885 |
| US-12319652-B2 | Salts and solid forms of (R)-1-(5-methoxy-1H-indol-1-yl)-N,N-dimethylpropan-2-amine | SLC6A4, GRIN2D, SLC1A2 | HTR2C 10/4885HTR2A 13/4885SLC6A2 6/4885 |
| US-20240034718-A1 | SALTS AND SOLID FORMS OF (R)-1-(5-METHOXY-1H-INDOL-1-YL)-N,N-DIMETHYLPROPAN-2-AMINE | SLC6A4, GRIN2D, SLC1A2 | HTR2C 10/4885HTR2A 13/4885SLC6A2 6/4885 |
| US-20250002456-A1 | SALTS AND SOLID FORMS OF (R)-1-(5-METHOXY-1H-INDOL-1-YL)-N,N-DIMETHYLPROPAN-2-AMINE | SLC6A4, GRIN2D, SLC1A2 | HTR2C 10/4885HTR2A 13/4885SLC6A2 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.