Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 9/20 | 0.46 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | PKM | P14618 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13385745 | 0.80 | GAA (0.66) | GAASMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL30397280 | 0.78 | NPC1 (0.66) | GAASMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL25233274 | 0.78 | NPC1 (0.66) | GAASMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL1357366 | 0.77 | GAA (0.56) | GAASMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL13060617 | 0.75 | GAA (0.66) | GAASMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL16345114 | 0.75 | GAA (0.59) | GAASMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL5359661 | 0.74 | GAA (0.66) | GAASMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL23388826 | 0.73 | SMN1; SMN2 (0.61) | GAASMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL29995352 | 0.73 | SMN1; SMN2 (0.61) | GAASMN1; SMN2RAB9ANPC1PKM | |
| Hydrochloric Acid SCHEMBL29117351 | 0.73 | HDAC6 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |