Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 20/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.65 |
| ▸ | HTR2B | P41595 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2438302 | 0.92 | GHSR (0.76) | GHSRCHRM2HTR2BKCNH2CYP3A4 | |
| SCHEMBL2439109 | 0.86 | GHSR (1.00) | GHSRCHRM2HTR2BKCNH2CYP3A4 | |
| SCHEMBL2431889 | 0.86 | GHSR (1.00) | GHSRCHRM2HTR2BKCNH2CYP3A4 | |
| SCHEMBL2442418 | 0.85 | GHSR (0.85) | GHSRCHRM2HTR2BKCNH2CYP3A4 | |
| SCHEMBL2441577 | 0.82 | GHSR (0.79) | GHSRCHRM2HTR2BKCNH2CYP3A4 | |
| SCHEMBL2444910 | 0.82 | GHSR (0.79) | GHSRCHRM2HTR2BKCNH2CYP3A4 | |
| SCHEMBL2431303 | 0.80 | GHSR (0.73) | GHSRCHRM2HTR2BKCNH2CYP3A4 | |
| SCHEMBL2435730 | 0.79 | GHSR (0.85) | GHSRCHRM2HTR2BKCNH2CYP3A4 | |
| SCHEMBL2436171 | 0.79 | GHSR (1.00) | GHSRCHRM2HTR2BKCNH2CYP3A4 | |
| SCHEMBL2440779 | 0.79 | GHSR (1.00) | GHSRCHRM2HTR2BKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547679-A1 | 2,3 DIHYDRO-1H-INDEN-1-YL- 2,7-DIAZASPIRO [3.6]NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | Pfizer Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011114271-A1 | 2,3 DIHYDRO-1H-INDEN-1-YL- 2,7-DIAZASPIRO [3.6] NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | PFIZER INC. (US) | 2011-09-22 | — | — | WO | disclosed |