Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.62 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2520705 | 0.78 | GRM5 (0.52) | GRM5APPADORA2AMAPTFFAR1 | |
| SCHEMBL17705931 | 0.77 | GRM5 (0.62) | GRM5APPADORA2APDGFRBPDGFRA | |
| SCHEMBL1642973 | 0.77 | GRM5 (0.61) | GRM5APPADORA2AMAPTFFAR1 | |
| SCHEMBL13516538 | 0.77 | GRM5 (0.61) | GRM5APPADORA2AMAPTFFAR1 | |
| SCHEMBL403731 | 0.77 | GRM5 (0.61) | GRM5APPADORA2AMAPTFFAR1 | |
| SCHEMBL14840580 | 0.77 | GRM5 (1.00) | GRM5APPADORA2APDGFRBPDGFRA | |
| SCHEMBL4860070 | 0.76 | GRM5 (1.00) | GRM5APPMAPT | |
| SCHEMBL4855998 | 0.74 | APP (0.50) | GRM5APPADORA2AMAPTFFAR1 | |
| Diphenylacetylene SCHEMBL960609 | 0.74 | APP (1.00) | GRM5APPMAPTFFAR1 | |
| Diphenylacetylene SCHEMBL29188592 | 0.74 | APP (1.00) | GRM5APPMAPTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882742-B1 | ARYLETHYNYL PYRIMIDINES | HOFFMANN LA ROCHE (CH) | 2016-09-21 | — | — | EP | disclosed |
| EP-2702050-B1 | PYRAZOLIDIN-3-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-05-18 | — | — | EP | disclosed |
| EP-2702050-B1 | PYRAZOLIDIN-3-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-05-18 | — | — | EP | disclosed |
| US-9315498-B2 | Arlethynyl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2016-04-19 | — | — | US | disclosed |
| US-9315498-B2 | Arlethynyl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2016-04-19 | — | — | US | disclosed |
| US-9315498-B2 | Arlethynyl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2016-04-19 | — | — | US | disclosed |
| EP-2558457-B1 | ARYLETHYNYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-03-09 | — | — | EP | disclosed |
| EP-2558457-B1 | ARYLETHYNYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-03-09 | — | — | EP | disclosed |
| US-9199971-B2 | Arylethynyl pyrimidines | HOFFMAN-LA ROCHE INC. (US) | 2015-12-01 | — | — | US | disclosed |
| EP-2882742-A1 | ARYLETHYNYL PYRIMIDINES | F. Hoffmann-La Roche AG (CH) | 2015-06-17 | — | — | EP | disclosed |
| US-8420661-B2 | Arylethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-8420661-B2 | Arylethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-8420661-B2 | Arylethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-04-16 | — | — | US | disclosed |
| EP-2558457-A1 | ARYLETHYNYL DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| WO-2012146552-A1 | PYRAZOLIDIN-3-ONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-01 | — | — | WO | disclosed |
| US-20120277243-A1 | PYRAZOLIDIN-3-ONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-01 | — | — | US | disclosed |
| US-20120277243-A1 | PYRAZOLIDIN-3-ONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-01 | — | — | US | disclosed |
| WO-2011128279-A1 | ARYLETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-20 | — | — | WO | disclosed |
| US-20110251169-A1 | Arylethynyl derivatives | HOFFMANN-LA ROCHE, INC. | 2011-10-13 | — | — | US | disclosed |
| US-20110251169-A1 | Arylethynyl derivatives | HOFFMANN-LA ROCHE, INC. | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277243-A1 | PYRAZOLIDIN-3-ONE DERIVATIVES | GRM5, GRM1, GRIK5 | GRM5 1/4885APP 3720/4885ADORA2A 311/4885 |
| US-20110251169-A1 | Arylethynyl derivatives | GRM5, GRM1, GRM3 | GRM5 1/4885APP 4040/4885ADORA2A 241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.