Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | GRM5 | P41594 | 6/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylacetylene SCHEMBL29188592 | 1.00 | APP (1.00) | APPMAPTGRM5CYP1A2CYP3A4 | |
| Diphenylacetylene SCHEMBL68254 | 1.00 | APP (1.00) | APPMAPTGRM5CYP1A2CYP3A4 | |
| Diphenylacetylene SCHEMBL29415615 | 0.96 | APP (0.92) | APPMAPTGRM5CYP1A2CYP3A4 | |
| Diphenylacetylene SCHEMBL31243352 | 0.96 | APP (0.92) | APPMAPTGRM5CYP1A2CYP3A4 | |
| Diphenylacetylene SCHEMBL28768551 | 0.96 | APP (0.92) | APPMAPTGRM5CYP1A2CYP3A4 | |
| Diphenylacetylene SCHEMBL23754282 | 0.96 | APP (0.92) | APPMAPTGRM5CYP1A2CYP3A4 | |
| Diphenylacetylene SCHEMBL28966277 | 0.96 | APP (0.92) | APPMAPTGRM5CYP1A2CYP3A4 | |
| Diphenylacetylene SCHEMBL9273707 | 0.96 | APP (0.92) | APPMAPTGRM5CYP1A2CYP3A4 | |
| Diphenylacetylene SCHEMBL5576302 | 0.96 | APP (0.92) | APPMAPTGRM5CYP1A2CYP3A4 | |
| Diphenylacetylene SCHEMBL31286315 | 0.96 | APP (0.92) | APPMAPTGRM5CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113874340-A | Selective hydrogenation of alkynes to alkenes in the presence of phosphorus compounds and organic sulfur compounds | 帝斯曼知识产权资产管理有限公司 | 2021-12-31 | — | — | CN | disclosed |
| US-9549988-B2 | Pharmaceutical compounds targeted by MIF affinity-tethered moieties | RJS Biologics (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150352217-A1 | Pharmaceutical Compounds Targeted by MIF Affinity-Tethered Moieties | RJS BIOLOGICS LLC | 2015-12-10 | — | — | US | disclosed |
| WO-2011017129-A1 | SUBSTITUTED 1,2-AZABORINE HETEROCYCLES | STATE OF OREGON ON BEHALF OF THE UNIVERSITY OF OREGON (US) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150352217-A1 | Pharmaceutical Compounds Targeted by MIF Affinity-Tethered Moieties | MIF, HMGB2, HMGB1 | APP 2802/4885MAPT 2168/4885GRM5 2991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.