Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.84 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.84 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.84 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.84 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.84 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.84 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.84 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.84 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.84 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.84 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.84 |
| ▸ | ABL1 | P00519 | 9/20 | 0.81 |
| ▸ | SRC | P12931 | 8/20 | 0.81 |
| ▸ | LCK | P06239 | 5/20 | 0.81 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.81 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.81 |
| ▸ | EGFR | P00533 | 2/20 | 0.81 |
| ▸ | FYN | P06241 | 2/20 | 0.81 |
| ▸ | CSF1R | P07333 | 2/20 | 0.81 |
| ▸ | YES1 | P07947 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30428970 | 1.00 | HDAC3 (0.84) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL30430113 | 0.98 | HDAC3 (0.85) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL25232237 | 0.98 | HDAC3 (0.85) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1147171 | 0.96 | HDAC3 (0.84) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1147164 | 0.94 | HDAC3 (0.82) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL30429232 | 0.93 | HDAC3 (0.87) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL25243991 | 0.93 | HDAC3 (0.87) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL29618215 | 0.92 | ABL1 (0.87) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL28935340 | 0.92 | ABL1 (0.87) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1146991 | 0.92 | HDAC3 (0.83) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122185-A1 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED N-(2-CHLORO-6-METHYLPHENYL)-2-((6-(6-MEMBERED HETEROCYCLOALKYL)-2-METHYLPYRIMIDIN-4-YL)AMINO)THIAZOLE-5-CARBOXAMIDE ANALOGUES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2025-04-17 | — | — | US | disclosed |
| WO-2023096995-A1 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED N-(2-CHLORO-6-METHYLPHENYL)-2-((6-(6-MEMBERED HETEROCYCLOALKYL)-2-METHYLPYRIMIDIN-4-YL)AMINO)THIAZOLE-5-CARBOXAMIDE ANALOGUES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) | 2023-06-01 | — | — | WO | disclosed |
| WO-2023096995-A1 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED N-(2-CHLORO-6-METHYLPHENYL)-2-((6-(6-MEMBERED HETEROCYCLOALKYL)-2-METHYLPYRIMIDIN-4-YL)AMINO)THIAZOLE-5-CARBOXAMIDE ANALOGUES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) | 2023-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122185-A1 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED N-(2-CHLORO-6-METHYLPHENYL)-2-((6-(6-MEMBERED HETEROCYCLOALKYL)-2-METHYLPYRIMIDIN-4-YL)AMINO)THIAZOLE-5-CARBOXAMIDE ANALOGUES | LCK, SRC, MARCKS | HDAC3 419/4885HDAC4 1529/4885HDAC1 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.