Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17054307 | 0.83 | MEN1 (0.53) | ALDH1A1SMN1; SMN2HTR1DHTR2AHTR2C | |
| SCHEMBL20075104 | 0.81 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HDAC6HTR1AHTR1D | |
| SCHEMBL15779008 | 0.81 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HTR1AHTR1DHTR2A | |
| SCHEMBL24052103 | 0.81 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HTR1AHTR1DHTR2A | |
| SCHEMBL16200385 | 0.81 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HTR1AHTR1DHTR2A | |
| SCHEMBL17054325 | 0.80 | IKBKB (0.53) | HTR1DHTR2AHTR2CHTR1EHTR7 | |
| SCHEMBL21501581 | 0.80 | DYRK1A (0.38) | ALDH1A1SMN1; SMN2HTR1DHTR2AHTR2C | |
| SCHEMBL11622606 | 0.79 | AKT2 (0.53) | ALDH1A1SMN1; SMN2ALPLKDM4EKMT2A | |
| SCHEMBL14370266 | 0.78 | CYP1A2 (0.47) | ALDH1A1SMN1; SMN2HDAC6HTR1AHTR1D | |
| SCHEMBL13162473 | 0.78 | LRRK2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026762-A1 | FUSED PYRAZOLE UREA ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-01-23 | — | — | US | disclosed |
| EP-4441034-A1 | FUSED PYRAZOLE UREA ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Merck Sharp & Dohme LLC (US) | 2024-10-09 | — | — | EP | disclosed |
| WO-2023101895-A1 | FUSED PYRAZOLE UREA ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026762-A1 | FUSED PYRAZOLE UREA ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GBA1, GBA2, UGCG | ALDH1A1 2176/4885SMN1; SMN2 1330/4885HDAC6 477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.