Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4282110 | 0.83 | HDAC1 (0.49) | HDAC1HDAC2CYP17A1MAP3K5P2RY14 | |
| SCHEMBL4282116 | 0.83 | HDAC1 (0.54) | HDAC1HDAC2CYP17A1MAP3K5P2RY14 | |
| SCHEMBL25244303 | 0.82 | HDAC1 (0.43) | HDAC1HDAC2CYP17A1MAP3K5P2RY14 | |
| SCHEMBL651518 | 0.78 | HDAC1 (0.52) | HDAC1HDAC2CYP17A1MAP3K5P2RY14 | |
| SCHEMBL10121375 | 0.78 | HDAC1 (0.49) | HDAC1HDAC2CYP17A1MAP3K5P2RY14 | |
| SCHEMBL8172813 | 0.78 | HDAC1 (0.46) | HDAC1HDAC2CYP17A1KCNH2PPARG | |
| SCHEMBL650277 | 0.77 | HDAC1 (0.48) | HDAC1HDAC2CYP17A1MAP3K5P2RY14 | |
| SCHEMBL3769556 | 0.76 | HDAC1 (0.48) | HDAC1HDAC2CYP17A1P2RY14HDAC3 | |
| SCHEMBL2686960 | 0.73 | HDAC1 (0.41) | HDAC1HDAC2CYP17A1MAP3K5P2RY14 | |
| SCHEMBL2685761 | 0.72 | HDAC1 (0.40) | HDAC1HDAC2CYP17A1MAP3K5P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043607-B2 | HDAC inhibitors and therapeutic use thereof | TANGO THERAPEUTICS, INC. (US) | 2024-07-23 | — | — | US | disclosed |
| US-20230174501-A1 | NOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF | TANGO THERAPEUTICS, INC. | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174501-A1 | NOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF | HDAC1, HDAC7, HDAC5 | HDAC1 1/4885HDAC2 9/4885CYP17A1 1294/4885 |
| US-12043607-B2 | HDAC inhibitors and therapeutic use thereof | HDAC1, HDAC7, HDAC5 | HDAC1 1/4885HDAC2 8/4885CYP17A1 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.