Bufexamac

Bufexamac

SCHEMBL25215

CCCCOc1ccc(CC(=O)NO)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2D6 P10635 1/20 1.00
PDE4A P27815 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
HIF1A Q16665 1/20 1.00
HDAC10 Q969S8 1/20 1.00
HDAC6 Q9UBN7 1/20 1.00
ALDH1A1 P00352 1/20 0.68
LMNA P02545 1/20 0.68
MMP1 P03956 4/20 0.61
ADAMTS4 O75173 1/20 0.57
MMP2 P08253 1/20 0.57
MMP13 P45452 1/20 0.57
MMP14 P50281 1/20 0.57
ADAMTS5 Q9UNA0 1/20 0.57
PLA2G4B P0C869 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bufexamac SCHEMBL5076113 1.00 KDM4E (1.00) KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2
Bufexamac SCHEMBL15456779 0.98 KDM4E (0.97) KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2
SCHEMBL2777642 0.93 CYP1A2 (0.88) KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2
Tetrabuthylammonium SCHEMBL15545861 0.93 KDM4E (0.86) KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2
Bufexamac SCHEMBL5495939 0.90 SMN1; SMN2 (0.81) KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2
SCHEMBL13597738 0.87 KDM4E (0.77) KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2
SCHEMBL21409744 0.87 KDM4E (0.77) KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2
SCHEMBL8290681 0.86 SMN1; SMN2 (0.76) KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2
SCHEMBL15456780 0.84 KDM4E (0.72) KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2
SCHEMBL3438778 0.84 KDM4E (0.72) KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7171 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260069532-A1 METHOD FOR MORSELIZING AND/OR TARGETING PHARMACEUTICALLY ACTIVE PRINCIPLES TO SYNOVIAL TISSUE MEDINCELL S.A. (FR) 2026-03-12 US claimed
US-12569861-B2 Compounds, methods, and systems for benefication of rare earth elements by flotation and gravity concentration COLORADO SCHOOL OF MINES (US) 2026-03-10 US claimed
US-12558309-B2 Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue MEDINCELL S.A. (FR) 2026-02-24 US claimed
WO-2025224317-A1 A METHOD FOR TARGETING PHARMACEUTICALLY ACTIVE PRINCIPLE IN TOTAL KNEE REPLACEMENT MEDINCELL S.A. (FR) 2025-10-30 WO claimed
US-20250177565-A1 METHODS AND MATERIALS FOR INHIBITING/PREVENTING THE TRAFFICKING OF MONOCYTES TO THE CENTRAL NERVOUS SYSTEM DARTMOUTH COLLEGE (US) 2025-06-05 US claimed
US-20250144056-A1 ANTIMICROBIAL HOST DEFENSE PEPTIDE-INDUCING COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL AND MECH COLLEGES (US) 2025-05-08 US claimed
WO-2025059442-A1 MODULATING PLANT RESPONSES TO STRESS AND GROWTH WITH CHEMICALS REMOTE EPIGENETICS INC. (US) 2025-03-20 WO claimed
WO-2025056970-A1 MAMMALIAN CELL CULTURE ADDITIVES VIROCELL BIOLOGICS LTD (GB) 2025-03-20 WO claimed
US-20250041208-A1 NEW INJECTABLE COMBINATION FORMULATION NANEXA AB (SE) 2025-02-06 US claimed
US-20250032483-A1 COMPOSITIONS AND METHODS FOR TREATING PAIN ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2025-01-30 US claimed
US-4765983-A INTESTINAL-SOLUBLE POLYMER AND MEDICAMENT YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1988-08-23 US claimed
EP-0253486-A1 Oral composition LION CORPORATION (JP) 1988-01-20 EP claimed
US-4661342-A ANTICARIES AGENTS LION CORPORATION (JP) 1987-04-28 US claimed
EP-0197876-A1 Therapeutical composition for use in dermatology containing imidazolidinyl urea as an active substance ANBEN (FR) 1986-10-15 EP claimed
EP-0116182-B1 Process for the preparation of finely divided p-butoxyphenyl acethydroxamic acid CONTINENTAL PHARMA, INC. (BE) 1986-09-03 EP claimed
EP-0158090-A1 Drug for the treatment and the protection of the skin Ismail, Roshdy, Dr. (DE) 1985-10-16 EP claimed
US-4534911-A DISSOLVING IN BASIC SOLUTION, PRECIPITATION FROM ACID SOLUTION IN PRESENCE OF SURFACTANT CONTINENTAL PHARMA, INC. (LI) 1985-08-13 US claimed
EP-0132431-A1 COMPACT DEVICE FOR STORING, TRANSPORTING AND PRESENTING CLOTHES. FELDINGER MEIR 1985-02-06 EP claimed
WO-1984002836-A1 COMPACT DEVICE FOR STORING, TRANSPORTING AND PRESENTING CLOTHES FELDINGER MEIR 1984-08-02 WO claimed
EP-0044063-A1 Hot gas generator Popp, Dieter (DE) 1982-01-20 EP claimed