Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | MMP1 | P03956 | 4/20 | 0.61 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.57 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bufexamac SCHEMBL25215 | 1.00 | KDM4E (1.00) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| Bufexamac SCHEMBL15456779 | 0.98 | KDM4E (0.97) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| SCHEMBL2777642 | 0.93 | CYP1A2 (0.88) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| Tetrabuthylammonium SCHEMBL15545861 | 0.93 | KDM4E (0.86) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| Bufexamac SCHEMBL5495939 | 0.90 | SMN1; SMN2 (0.81) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| SCHEMBL13597738 | 0.87 | KDM4E (0.77) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| SCHEMBL21409744 | 0.87 | KDM4E (0.77) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| SCHEMBL8290681 | 0.86 | SMN1; SMN2 (0.76) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| SCHEMBL15456780 | 0.84 | KDM4E (0.72) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| SCHEMBL3438778 | 0.84 | KDM4E (0.72) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423056-A1 | METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK-3-ALPHA INHIBITORS | Frequency Therapeutics, Inc. (US) | 2019-01-09 | — | — | EP | disclosed |
| EP-3423069-A2 | METHODS FOR CONTROLLED PROLIFERATION OF VESTIBULAR STEM CELLS / GENERATING INNER EAR HAIR CELLS USING WNT AND TGF-BETA INHIBITION | Frequency Therapeutics, Inc. (US) | 2019-01-09 | — | — | EP | disclosed |
| EP-1956906-A2 | METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF MEDICAL CONDITIONS | CombinatoRx, Incorporated (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007056457-A2 | METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF MEDICAL CONDITIONS | COMBINATORX, INCORPORATED (US) | 2007-05-18 | — | — | WO | disclosed |
| US-5462969-A | Administering a mixture of an iron chelator and pentamide | NEW YORK UNIVERSITY (US) | 1995-10-31 | — | — | US | disclosed |
| US-5302598-A | Administering an iron chelator and trimethoprim/sulfamethoxazole to treat and prevent AIDS-related pneumonia | NEW YORK UNIVERSITY (US) | 1994-04-12 | — | — | US | disclosed |
| US-5158979-A | Administering iron chelator | NEW YORK UNIVERSITY (US) | 1992-10-27 | — | — | US | disclosed |