Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 8/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768608 | 1.00 | JAK2 (0.40) | JAK2JAK3JAK1BTKFGFR1 | |
| SCHEMBL26617088 | 0.87 | JAK2 (0.36) | JAK2JAK3JAK1KDM5A | |
| SCHEMBL26617086 | 0.87 | JAK2 (0.36) | JAK2JAK3JAK1KDM5A | |
| SCHEMBL21114946 | 0.83 | GPR119 (0.40) | JAK2JAK1BTKEGFRSRC | |
| SCHEMBL21114947 | 0.83 | GPR119 (0.40) | JAK2JAK1BTKEGFRSRC | |
| SCHEMBL28703609 | 0.83 | GPR119 (0.40) | JAK2JAK1BTKEGFRSRC | |
| SCHEMBL26617082 | 0.82 | FGFR1 (0.34) | JAK2JAK3JAK1FGFR1FGFR4 | |
| SCHEMBL26617081 | 0.82 | FGFR1 (0.34) | JAK2JAK3JAK1FGFR1FGFR4 | |
| SCHEMBL21192561 | 0.80 | FGFR1 (0.42) | BTKFGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL28766362 | 0.80 | FGFR1 (0.42) | BTKFGFR1FGFR4FGFR3FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107870-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES | KINNATE BIOPHARMA INC. (US) | 2023-06-15 | — | — | WO | disclosed |
| CN-115867547-A | 1H-pyrazole-4-amide derivative, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-109843873-B | Alkyne heterocyclic compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-06-17 | — | — | CN | disclosed |