Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30447687 | 1.00 | PIK3CA (0.47) | PIK3CAHTTCYP1A2CYP2C9TSHR | |
| SCHEMBL25256747 | 0.78 | PIK3CA (0.51) | PIK3CAHTTCYP1A2CYP2C9TSHR | |
| SCHEMBL31277403 | 0.78 | PIK3CA (0.51) | PIK3CAHTTCYP1A2CYP2C9TSHR | |
| SCHEMBL30448143 | 0.73 | PIK3CA (0.53) | PIK3CAPIK3R1EGLN1 | |
| SCHEMBL25251216 | 0.73 | PIK3CA (0.53) | PIK3CAPIK3R1EGLN1 | |
| SCHEMBL25402946 | 0.72 | PIK3CA (0.60) | PIK3CAPOLBPIK3R1 | |
| SCHEMBL30503099 | 0.72 | PIK3CA (0.60) | PIK3CAPOLBPIK3R1 | |
| SCHEMBL25219061 | 0.71 | PIK3CA (0.59) | PIK3CAHTTITKALDH1A1SMN1; SMN2 | |
| SCHEMBL30446982 | 0.71 | PIK3CA (0.59) | PIK3CAHTTITKALDH1A1SMN1; SMN2 | |
| SCHEMBL25403044 | 0.70 | PIK3CA (0.63) | PIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107603-A1 | PYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023107603-A1 | PYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |