⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12295340 | 0.64 | GRM5 (0.37) | — | |
| SCHEMBL10340172 | 0.64 | ACACB (0.35) | — | |
| SCHEMBL12254186 | 0.63 | EGLN1 (0.37) | — | |
| SCHEMBL13499904 | 0.63 | HSP90AA1 (0.38) | — | |
| SCHEMBL1761777 | 0.63 | — | — | |
| SCHEMBL11384 | 0.61 | — | — | |
| SCHEMBL14571166 | 0.61 | MAPT (0.42) | — | |
| SCHEMBL24528589 | 0.60 | GRM5 (0.62) | — | |
| SCHEMBL18471264 | 0.60 | MAPT (0.32) | — | |
| SCHEMBL5740851 | 0.60 | MAPT (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110251190-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-10-13 | — | — | US | claimed |
| US-8883782-B2 | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-20110251190-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-10-13 | — | — | US | disclosed |