Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25226836 | 0.86 | JAK2 (0.44) | JAK2JAK1TYK2JAK3PIK3CG | |
| SCHEMBL24849280 | 0.84 | PIK3CG (0.45) | JAK2JAK1TYK2JAK3PIK3CG | |
| SCHEMBL25271218 | 0.81 | JAK2 (0.40) | JAK2JAK1TYK2JAK3PIK3CG | |
| SCHEMBL23209295 | 0.80 | JAK2 (0.42) | JAK2JAK1TYK2JAK3PIK3CG | |
| SCHEMBL25223046 | 0.80 | JAK2 (0.45) | JAK2JAK1TYK2JAK3PIK3CG | |
| SCHEMBL25231152 | 0.79 | JAK2 (0.40) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL25245334 | 0.79 | JAK2 (0.49) | JAK2JAK1TYK2JAK3PIK3CG | |
| SCHEMBL25228287 | 0.78 | JAK2 (0.40) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL23209298 | 0.78 | JAK2 (0.42) | JAK2JAK1TYK2JAK3CD274 | |
| SCHEMBL30410992 | 0.77 | JAK1 (0.49) | JAK2JAK1TYK2JAK3CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12084453-B2 | Bicyclic amines as CDK12 inhibitors | INCYTE CORPORATION (US) | 2024-09-10 | — | — | US | disclosed |
| WO-2023107705-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023107705-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-15 | — | — | WO | disclosed |
| US-20230183251-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | INCYTE CORPORATION | 2023-06-15 | — | — | US | disclosed |
| US-20230183251-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | INCYTE CORPORATION | 2023-06-15 | — | — | US | disclosed |
| US-20230183251-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | INCYTE CORPORATION | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183251-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | CDK12, CDK1, CDK2 | JAK2 379/4885JAK1 672/4885TYK2 296/4885 |
| US-12084453-B2 | Bicyclic amines as CDK12 inhibitors | CDK12, CDK1, CDK2 | JAK2 379/4885JAK1 672/4885TYK2 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.