Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 6/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25231152 | 0.81 | JAK2 (0.40) | JAK1NUDT1JAK2JAK3TYK2 | |
| SCHEMBL23209298 | 0.81 | JAK2 (0.42) | JAK1NUDT1JAK2JAK3TYK2 | |
| SCHEMBL25228287 | 0.81 | JAK2 (0.40) | JAK1NUDT1JAK2JAK3TYK2 | |
| SCHEMBL25278273 | 0.79 | JAK2 (0.38) | JAK1JAK2JAK3TYK2CD274 | |
| SCHEMBL25675097 | 0.79 | JAK2 (0.39) | JAK1JAK2JAK3TYK2CD274 | |
| SCHEMBL23209265 | 0.78 | JAK2 (0.44) | JAK1JAK2JAK3TYK2CD274 | |
| SCHEMBL25231239 | 0.78 | JAK2 (0.41) | JAK1JAK2JAK3TYK2CD274 | |
| SCHEMBL25227853 | 0.78 | JAK2 (0.38) | JAK1EGLN2JAK2JAK3TYK2 | |
| SCHEMBL25224447 | 0.77 | JAK2 (0.44) | JAK1JAK2JAK3TYK2CD274 | |
| SCHEMBL3210559 | 0.77 | JAK2 (0.58) | JAK1NUDT1EGLN2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111320624-B | Triazolopyridine and imidazopyridine compounds, and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2023-05-12 | — | — | CN | disclosed |