Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | INSR | P06213 | 3/20 | 0.48 |
| ▸ | NPM1 | P06748 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 8/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522279 | 0.86 | JAK2 (0.53) | ALKINSRNPM1JAK2CYP3A4 | |
| SCHEMBL520675 | 0.86 | ALK (0.57) | ALKFLT3INSRNPM1JAK2 | |
| SCHEMBL2508745 | 0.81 | ALK (0.48) | ALKFLT3INSRJAK2CYP3A4 | |
| SCHEMBL520669 | 0.80 | JAK2 (0.59) | ALKFLT3INSRJAK2KCNH2 | |
| SCHEMBL522567 | 0.80 | ALK (0.65) | ALKFLT3INSRNPM1JAK2 | |
| SCHEMBL521274 | 0.79 | JAK2 (0.61) | ALKFLT3INSRNPM1JAK2 | |
| SCHEMBL521346 | 0.78 | JAK2 (0.54) | ALKFLT3INSRJAK2CYP3A4 | |
| SCHEMBL521816 | 0.77 | JAK2 (0.51) | ALKFLT3INSRJAK2 | |
| SCHEMBL16530527 | 0.77 | ALK (0.50) | ALKFLT3INSRJAK2CYP3A4 | |
| SCHEMBL522205 | 0.77 | JAK2 (0.53) | ALKFLT3INSRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |