Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.48 |
| ▸ | INSR | P06213 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 13/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520078 | 0.83 | JAK2 (0.59) | ALKINSRJAK2CYP3A4 | |
| SCHEMBL521112 | 0.83 | JAK2 (0.61) | ALKINSRJAK2CYP3A4 | |
| SCHEMBL2522652 | 0.81 | ALK (0.51) | ALKINSRJAK2CYP3A4FLT3 | |
| SCHEMBL2524303 | 0.79 | ALK (0.54) | ALKINSRJAK2CYP3A4 | |
| Cyclopropane SCHEMBL16530432 | 0.78 | ALK (0.56) | ALKINSRJAK2CYP3A4 | |
| SCHEMBL2526580 | 0.78 | ALK (0.58) | ALKINSRJAK2CYP3A4 | |
| SCHEMBL2502412 | 0.77 | ALK (0.55) | ALKINSRJAK2CYP3A4 | |
| SCHEMBL521823 | 0.77 | JAK2 (0.62) | ALKINSRJAK2FLT3 | |
| SCHEMBL2515163 | 0.75 | ALK (0.52) | ALKINSRJAK2CYP3A4 | |
| SCHEMBL16531842 | 0.74 | ALK (0.84) | ALKINSRJAK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | claimed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | claimed |