Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 14/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30397591 | 1.00 | HCRTR1 (0.41) | HCRTR1HCRTR2TRPM8CHRM4TRPV1 | |
| SCHEMBL30397933 | 0.79 | PTGDR2 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL30397528 | 0.76 | PTGDR2 (0.39) | HCRTR1HCRTR2TRPV1 | |
| SCHEMBL25228876 | 0.76 | PTGDR2 (0.39) | HCRTR1HCRTR2TRPV1 | |
| SCHEMBL25419552 | 0.65 | MAPK8 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL27233710 | 0.64 | CDK12 (0.56) | HCRTR1 | |
| SCHEMBL27233778 | 0.64 | CDK12 (0.56) | HCRTR1 | |
| SCHEMBL27233705 | 0.64 | CDK12 (0.56) | HCRTR1 | |
| SCHEMBL23292270 | 0.64 | USP30 (0.51) | TRPV1 | |
| SCHEMBL22895379 | 0.64 | USP30 (0.51) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |