Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | JUN | P05412 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | VCP | P55072 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2954274 | 1.00 | AKR1C3 (0.64) | AKR1C3KMT2AALDH1A1MEN1POLB | |
| SCHEMBL2523084 | 1.00 | AKR1C3 (0.64) | AKR1C3KMT2AALDH1A1MEN1POLB | |
| SCHEMBL2526753 | 0.95 | AKR1C3 (0.64) | AKR1C3KMT2AALDH1A1MEN1POLB | |
| SCHEMBL12215328 | 0.95 | AKR1C3 (0.64) | AKR1C3KMT2AALDH1A1MEN1POLB | |
| SCHEMBL12215323 | 0.92 | ALDH1A1 (0.56) | AKR1C3KMT2AALDH1A1MEN1AKR1C2 | |
| SCHEMBL3670551 | 0.91 | KDM4E (0.67) | AKR1C3KMT2AALDH1A1MEN1POLB | |
| SCHEMBL3670549 | 0.91 | KDM4E (0.67) | AKR1C3KMT2AALDH1A1MEN1POLB | |
| SCHEMBL31510188 | 0.86 | AKR1C3 (0.66) | AKR1C3KMT2AALDH1A1MEN1POLB | |
| SCHEMBL28462838 | 0.86 | AKR1C3 (0.63) | AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL28469876 | 0.86 | AKR1C3 (0.63) | AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1801087-B1 | CIS-1,2-SUBSTITUTED STILBENE DERIVATIVES FOR TREATING AND/OR PREVENTING DIABETES | INST RADIATION MED AMMS PLA (CN) | 2012-08-29 | — | — | EP | disclosed |
| US-8039513-B2 | Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes | INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA (CN) | 2011-10-18 | — | — | US | disclosed |
| US-7759527-B2 | Microwave induced one pot process for the preparation of arylethenes | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-07-20 | — | — | US | disclosed |
| US-20090161561-A1 | Method and system for determining characters of channels | HUAWEI TECHNOLOGIES CO., LTD | 2009-06-25 | — | — | US | disclosed |
| US-20090076114-A1 | Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes | INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA (CN) | 2009-03-19 | — | — | US | disclosed |
| US-20080045752-A1 | Microwave Induced One Pot Process For The Preparation Of Arylethenes | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-02-21 | — | — | US | disclosed |
| WO-2007110881-A1 | A MICROWAVE INDUCED ONE POT PROCESS FOR THE PREPARATION OF ARYLETHENES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2007-10-04 | — | — | WO | disclosed |
| EP-1801087-A1 | CIS-1,2-SUBSTITUTED STILBENE DERIVATES AND THE USE THEREROF FOR MANUFACTURING MEDICAMENTS FOR TREATING MEDICAMENTS FOR TREATING AND/OR PREVENTING DIABETES | Institute of Radiation Medicine, Academy of Military Medical Sciences Pla (CN) | 2007-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045752-A1 | Microwave Induced One Pot Process For The Preparation Of Arylethenes | TET2, HCN4, KDM4E | AKR1C3 1213/4885KMT2A 36/4885ALDH1A1 908/4885 |
| US-20090076114-A1 | Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes | SLC5A1, SLC5A2, SLC2A1 | AKR1C3 441/4885KMT2A 4751/4885ALDH1A1 413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.