Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 14/20 | 0.50 |
| ▸ | LPL | P06858 | 13/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29644319 | 0.85 | LPL (0.62) | LIPGLPLIRAK4CA1CA2 | |
| SCHEMBL1293460 | 0.85 | LPL (0.62) | LIPGLPLIRAK4CA1CA2 | |
| SCHEMBL29387132 | 0.83 | LPL (0.61) | LIPGLPLIRAK4CA1CA2 | |
| SCHEMBL1294059 | 0.83 | LPL (0.61) | LIPGLPLIRAK4CA1CA2 | |
| SCHEMBL2708689 | 0.81 | LPL (0.59) | LIPGLPLIRAK4CA1CA2 | |
| SCHEMBL4299809 | 0.81 | LPL (0.59) | LIPGLPLIRAK4CA1CA2 | |
| SCHEMBL6126262 | 0.79 | LPL (0.53) | LIPGLPLIRAK4CA1CA2 | |
| SCHEMBL29392121 | 0.78 | LPL (0.75) | LIPGLPLIRAK4CA1CA2 | |
| SCHEMBL1627177 | 0.78 | LPL (0.51) | LIPGLPLIRAK4CA1CA2 | |
| SCHEMBL120527 | 0.78 | LPL (0.75) | LIPGLPLIRAK4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373169-A1 | IMIDAZOPYRAZINE SYK INHIBITORS | Gilead Connecticut, Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010068257-A1 | IMIDAZOPYRAZINE SYK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |