Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.38 |
| ▸ | JAK1 | P23458 | 9/20 | 0.38 |
| ▸ | TYK2 | P29597 | 9/20 | 0.38 |
| ▸ | JAK3 | P52333 | 9/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25242656 | 0.86 | L3MBTL1 (0.36) | KDM4EELANEL3MBTL1 | |
| SCHEMBL25241903 | 0.81 | KMT2A (0.39) | KDM4E | |
| SCHEMBL12493990 | 0.80 | JAK2 (0.54) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL3458337 | 0.79 | JAK2 (0.46) | JAK2JAK1TYK2JAK3ADRA1A | |
| SCHEMBL9102971 | 0.79 | JAK2 (0.43) | JAK2JAK1TYK2JAK3TGFBR1 | |
| SCHEMBL25240695 | 0.78 | JAK2 (0.35) | JAK2JAK1TYK2JAK3TGFBR1 | |
| SCHEMBL25776500 | 0.78 | JAK2 (0.42) | JAK2JAK1TYK2JAK3TGFBR1 | |
| SCHEMBL25421804 | 0.74 | MAP4K4 (0.36) | — | |
| SCHEMBL13731284 | 0.73 | PARP1 (0.33) | JAK2JAK1TYK2JAK3RIPK2 | |
| SCHEMBL30736370 | 0.71 | SIRT3 (0.46) | JAK2TGFBR1ADRA1AIRAK4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116779-A1 | DIALKYNE COMPOUND AND USE THEREOF | 上海艾力斯医药科技股份有限公司 | 2023-06-29 | — | — | WO | disclosed |