Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 15/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25244450 | 0.83 | TTK (0.41) | TTKCCNA2CDK2LRRK2 | |
| SCHEMBL25287077 | 0.79 | TYK2 (0.36) | TTKCCNA2CDK2LRRK2 | |
| SCHEMBL25242037 | 0.71 | TTK (0.52) | TTKCCNA2CDK2 | |
| SCHEMBL23299605 | 0.68 | MKNK1 (0.52) | LRRK2ABL1BCR | |
| SCHEMBL25292442 | 0.67 | TTK (0.41) | TTKCCNA2CDK2LRRK2 | |
| SCHEMBL22025414 | 0.65 | TTK (1.00) | TTKCCNA2CDK2 | |
| SCHEMBL30606110 | 0.64 | LRRK2 (0.44) | TTKCCNA2CDK2CHEK1KCNH2 | |
| SCHEMBL14948607 | 0.64 | LRRK2 (0.44) | TTKCCNA2CDK2CHEK1KCNH2 | |
| SCHEMBL13354459 | 0.63 | PIM1 (0.50) | CHEK1LRRK2ABL1BCR | |
| SCHEMBL25245407 | 0.63 | GRM5 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |