Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 16/20 | 0.54 |
| ▸ | JAK1 | P23458 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25289314 | 0.89 | TYK2 (0.69) | TYK2JAK1KCNH2 | |
| SCHEMBL25242045 | 0.87 | TYK2 (0.58) | TYK2JAK1KCNH2 | |
| SCHEMBL25294035 | 0.84 | TYK2 (0.56) | TYK2JAK1KCNH2 | |
| SCHEMBL25243960 | 0.80 | TYK2 (0.54) | TYK2JAK1AKR1C3KCNH2 | |
| SCHEMBL25243633 | 0.79 | TYK2 (0.47) | TYK2JAK1 | |
| SCHEMBL25244793 | 0.78 | TYK2 (0.57) | TYK2JAK1KCNH2 | |
| SCHEMBL25251672 | 0.78 | TYK2 (0.51) | TYK2JAK1KCNH2 | |
| SCHEMBL25282307 | 0.78 | TYK2 (0.54) | TYK2JAK1 | |
| SCHEMBL25242097 | 0.76 | TYK2 (0.52) | TYK2JAK1POLBGAA | |
| SCHEMBL25293421 | 0.73 | GAA (0.53) | TYK2JAK1POLBGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |