Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PHGDH | O43175 | 6/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11623533 | 0.80 | KMT2A (0.50) | KMT2AKDM4EPHGDHADORA1CYP1A2 | |
| SCHEMBL17261556 | 0.78 | ALDH1A1 (0.43) | KMT2AKDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL17261466 | 0.78 | ALDH1A1 (0.43) | KMT2AKDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL17261471 | 0.78 | ALDH1A1 (0.43) | KMT2AKDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL12777940 | 0.77 | KMT2A (0.59) | KMT2AKDM4EALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL17261487 | 0.76 | MAPT (0.47) | KMT2AKDM4EALDH1A1PHGDHADORA1 | |
| SCHEMBL17261473 | 0.75 | AR (0.44) | KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL17261490 | 0.75 | AR (0.44) | KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL11621690 | 0.75 | KMT2A (0.45) | KMT2AKDM4EALDH1A1PHGDHMEN1 | |
| SCHEMBL17261561 | 0.74 | KMT2A (0.41) | KMT2AKDM4EALDH1A1PHGDHADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2375899-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | Array Biopharma, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010080864-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2010-07-15 | — | — | WO | disclosed |