Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.51 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.51 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.51 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.51 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.51 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.51 |
| ▸ | BDKRB2 known ✓ | P30411 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | APAF1 | O14727 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | RAD52 | P43351 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11139244 | 0.84 | KDM4E (0.43) | SMN1; SMN2ALDH1A1TDP1MEN1TP53 | |
| Hydrochloric Acid SCHEMBL2524643 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1TDP1CYP3A4HIF1A | |
| SCHEMBL10878637 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1TDP1CYP3A4HIF1A | |
| Hydrochloric Acid SCHEMBL1627409 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1TDP1CYP3A4HIF1A | |
| Hydrochloric Acid SCHEMBL11179543 | 0.75 | PTGS1 (0.35) | ALDH1A1TDP1LMNATSHRACHE | |
| Hydrochloric Acid SCHEMBL11659853 | 0.74 | MEN1 (0.43) | SMN1; SMN2TDP1MEN1TP53KMT2A | |
| SCHEMBL9632633 | 0.73 | CYP3A4 (0.46) | SMN1; SMN2ALDH1A1TDP1CYP3A4HIF1A | |
| Hydrochloric Acid SCHEMBL11253648 | 0.73 | SMN1; SMN2 (0.72) | SMN1; SMN2ALDH1A1TDP1CYP3A4HIF1A | |
| Hydrochloric Acid SCHEMBL8695973 | 0.73 | MEN1 (0.57) | SMN1; SMN2ALDH1A1TDP1CYP3A4HIF1A | |
| SCHEMBL9702929 | 0.72 | PPARG (0.34) | SLC6A2SLC6A4SLC6A3PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8292995-B2 | Sulfonated dye salts having improved stability | SILVERBROOK RESEARCH PTY LTD (AU) | 2012-10-23 | — | — | US | disclosed |
| US-8038737-B2 | Method of modulating stability of sulfonated dye | SILVERBROOK RESEARCH PTY LTD (AU) | 2011-10-18 | — | — | US | disclosed |
| US-20090255986-A1 | METHOD OF INITIATING ACTION IN COMPUTER SYSTEM VIA ANALOG-PRINTED SUBSTRATE | SILVERBROOK RESEARCH PTY LTD | 2009-10-15 | — | — | US | disclosed |
| US-20090199352-A1 | METHOD OF MODULATING STABILITY OF SULFONATED DYE | SILVERBROOK RESEARCH PTY LTD | 2009-08-13 | — | — | US | disclosed |
| US-20090202799-A1 | SULFONATED DYE SALTS HAVING IMPROVED STABILITY | SILVERBROOK RESEARCH PTY LTD | 2009-08-13 | — | — | US | disclosed |
| US-7566363-B2 | Alternative phthalocyanine dyes suitable for use in offset inks | SILVERBROOK RESEARCH PTY LTD (AU) | 2009-07-28 | — | — | US | disclosed |
| US-20090035533-A1 | ALTERNATIVE PHTHALOCYANINE DYES SUITABLE FOR USE IN OFFSET INKS | SILVERBROOK RESEARCH PTY LTD | 2009-02-05 | — | — | US | disclosed |
| US-4578489-A | MICROBIOCIDES; WATER SOLUBILITY | CIBA-GEIGY CORPORATION (US) | 1986-03-25 | — | — | US | disclosed |