Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.53 |
| ▸ | CA2 | P00918 | 6/20 | 0.53 |
| ▸ | CA12 | O43570 | 5/20 | 0.53 |
| ▸ | CA9 | Q16790 | 5/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 6/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25258787 | 0.96 | CA1 (0.53) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL25297430 | 0.90 | CA1 (0.52) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL25250315 | 0.89 | CA1 (0.53) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL1541945 | 0.89 | CA1 (0.64) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL25250103 | 0.88 | CYP2D6 (0.45) | CA1CA2CA12CA9BCHE | |
| SCHEMBL25289836 | 0.84 | CA1 (0.49) | CA1CA2CA12CA9NAMPT | |
| SCHEMBL23291379 | 0.83 | SUCNR1 (0.54) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL23291191 | 0.83 | SUCNR1 (0.54) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL23928228 | 0.83 | SUCNR1 (0.54) | CA1CA2CA12CA9SUCNR1 | |
| SCHEMBL23291233 | 0.83 | SUCNR1 (0.54) | CA1CA2CA12CA9SUCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A9 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |