Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.49 |
| ▸ | CA2 | P00918 | 6/20 | 0.49 |
| ▸ | CA12 | O43570 | 5/20 | 0.49 |
| ▸ | CA9 | Q16790 | 5/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25258787 | 0.89 | CA1 (0.53) | CA1CA2CA12CA9HDAC8 | |
| SCHEMBL24675647 | 0.89 | CA12 (0.49) | CA1CA2CA12CA9FAAH | |
| SCHEMBL24675764 | 0.87 | GLS (0.47) | CA1CA2CA12CA9HDAC8 | |
| SCHEMBL24675795 | 0.87 | GLS (0.47) | CA1CA2CA12CA9HDAC8 | |
| SCHEMBL19821728 | 0.84 | CA12 (0.54) | CA1CA2CA12CA9FAAH | |
| SCHEMBL25251532 | 0.84 | CA1 (0.53) | CA1CA2CA12CA9ALDH1A1 | |
| SCHEMBL24675890 | 0.83 | GLS (0.45) | CA1CA2CA12CA9HDAC8 | |
| SCHEMBL21100866 | 0.82 | HDAC1 (0.48) | CA1CA2CA12CA9FAAH | |
| SCHEMBL30670755 | 0.82 | L3MBTL1 (0.51) | CA1CA2CA12CA9FAAH | |
| SCHEMBL25289842 | 0.82 | GLS (0.46) | CA1CA2CA12CA9HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A9 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |