Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.43 |
| ▸ | LCAT | P04180 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30395333 | 1.00 | MAP4K4 (0.50) | MAP4K4KDM4EMAPTPDE10AGRIN2D | |
| SCHEMBL31541404 | 0.88 | GRIN2D (0.44) | MAP4K4KDM4EMAPTPDE10AGRIN2D | |
| SCHEMBL17316304 | 0.84 | GRIN2D (0.48) | KDM4EMAPTPDE10AGRIN2DGRIN3B | |
| SCHEMBL15205475 | 0.84 | GRIN2D (0.48) | KDM4EMAPTPDE10AGRIN2DGRIN3B | |
| SCHEMBL17316509 | 0.84 | GRIN2D (0.48) | KDM4EMAPTPDE10AGRIN2DGRIN3B | |
| SCHEMBL17696406 | 0.82 | MAP4K4 (0.50) | MAP4K4KDM4EMAPTPDE10AGRIN2D | |
| SCHEMBL15206004 | 0.81 | AKR1C3 (0.52) | KDM4EMAPTPDE10AGRIN2DGRIN3B | |
| SCHEMBL17210352 | 0.80 | MAP4K4 (0.41) | MAP4K4KDM4EMAPTTRPV3CYP3A4 | |
| SCHEMBL390612 | 0.77 | GRIN2D (0.47) | MAP4K4PDE10AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL21861463 | 0.77 | MAPT (0.48) | MAP4K4KDM4EMAPTPDE10AGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981661-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2024-05-14 | — | — | US | disclosed |
| EP-4208456-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2023-07-12 | — | — | EP | disclosed |
| CN-115989228-A | Heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2023-04-18 | — | — | CN | disclosed |
| US-20220098176-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2022-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220098176-A1 | HETEROCYCLIC COMPOUNDS | CBR3, BRIX1, CCNY | MAP4K4 3829/4885KDM4E 1570/4885MAPT 4401/4885 |
| US-11981661-B2 | Heterocyclic compounds | CBR3, BRIX1, CCNY | MAP4K4 3829/4885KDM4E 1570/4885MAPT 4401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.