SCHEMBL25253573

SCHEMBL25253573

Nc1cnnc2cc(-c3ccc(C(F)(F)F)c(B(O)OC=O)c3)ccc12

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 1/20 0.31
TRPV1 Q8NER1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formic Acid SCHEMBL25253575 0.86 PDE10A (0.33) PDE10ATRPV1
Formic Acid SCHEMBL30467685 0.86 PDE10A (0.33) PDE10ATRPV1
SCHEMBL25244081 0.85 PDE10A (0.39) PDE10A
SCHEMBL24252270 0.84 PDE10A (0.36) PDE10ATRPV1
SCHEMBL26771225 0.82 PDE10A (0.34) PDE10ATRPV1
SCHEMBL25209996 0.79 CDK9 (0.30)
SCHEMBL25245402 0.77
SCHEMBL25212150 0.75 SCN9A (0.37) PDE10A
SCHEMBL25213122 0.74 PDE10A (0.39) PDE10A
SCHEMBL25217989 0.74 PDE10A (0.32) PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 US disclosed
EP-4185592-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2023-05-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 PDE10A 1950/4885TRPV1 3867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.