Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25257990 | 0.88 | TLR8 (0.43) | TLR7TLR8L3MBTL1 | |
| SCHEMBL31270698 | 0.88 | TLR8 (0.43) | TLR7TLR8L3MBTL1 | |
| SCHEMBL25296123 | 0.87 | TLR7 (0.48) | TLR7TLR8LMNAGAAHTT | |
| SCHEMBL25256134 | 0.85 | RAB9A (0.39) | TLR7LMNAGAAHTTNPSR1 | |
| SCHEMBL29263606 | 0.84 | TLR7 (0.40) | TLR7TLR8LMNACTDSP1TDP1 | |
| SCHEMBL9940820 | 0.83 | TLR7 (0.45) | TLR7TLR8LMNARAB9AATM | |
| SCHEMBL1950513 | 0.80 | TLR7 (0.45) | TLR7TLR8GAAHTTRAB9A | |
| SCHEMBL3862584 | 0.80 | TLR7 (0.39) | TLR7TLR8RAB9ATDP1ALDH1A1 | |
| SCHEMBL3865204 | 0.77 | NMT1 (0.45) | LMNAL3MBTL1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL1486736 | 0.77 | BRD4 (0.40) | TLR7ALDH1A1SMN1; SMN2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125121-A1 | TRICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2023-07-06 | — | — | WO | disclosed |