Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25209171 | 0.83 | KDM4E (0.55) | LMNAKDM4EKMT2AMEN1MAPT | |
| SCHEMBL22346601 | 0.77 | KDM4E (0.53) | LMNAKDM4EKMT2AMEN1MAPT | |
| SCHEMBL26688411 | 0.76 | KDM4E (0.55) | LMNAKDM4EKMT2AMEN1MAPT | |
| SCHEMBL22346715 | 0.74 | KDM4E (0.53) | LMNAKDM4EKMT2AMEN1MAPT | |
| SCHEMBL25229367 | 0.73 | KDM4E (0.42) | LMNAKDM4EKMT2AMEN1MAPT | |
| SCHEMBL22346724 | 0.72 | KDM4E (0.54) | LMNAKDM4EKMT2AMEN1MAPT | |
| SCHEMBL25255359 | 0.72 | LMNA (0.51) | LMNAKDM4EKMT2AMEN1MAPT | |
| SCHEMBL29364718 | 0.72 | LMNA (0.51) | LMNAKDM4EKMT2AMEN1MAPT | |
| SCHEMBL12346514 | 0.71 | LMNA (1.00) | LMNAKDM4EKMT2AMEN1MAPT | |
| SCHEMBL25217094 | 0.71 | LMNA (0.65) | LMNAKDM4EKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4185293-A1 | COMPOSITIONS AND METHODS FOR ACTIVATING PYRUVATE KINASE | The Regents of The University of Michigan (US) | 2023-05-31 | — | — | EP | disclosed |
| WO-2022020424-A1 | COMPOSITIONS AND METHODS FOR ACTIVATING PYRUVATE KINASE | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-01-27 | — | — | WO | disclosed |