Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.34 |
| ▸ | GCGR | P47871 | 6/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31230008 | 1.00 | PDE1A (0.39) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL26315307 | 0.76 | GCGR (0.34) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL31230019 | 0.72 | PIK3CA (0.48) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL25214678 | 0.72 | PIK3CA (0.48) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL25267720 | 0.69 | CLK1 (0.38) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL25626407 | 0.67 | MAPK1 (0.41) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL31230009 | 0.67 | MAPK1 (0.41) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL3116382 | 0.61 | HTT (0.55) | MAPK9KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL18058368 | 0.61 | MAPT (0.43) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL3465338 | 0.61 | DAO (0.38) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444317-A2 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107623-A2 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |