Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 7/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25259210 | 0.76 | PDE1A (0.39) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL31230008 | 0.76 | PDE1A (0.39) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL30677355 | 0.73 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL20524214 | 0.73 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL25626411 | 0.72 | PIK3CA (0.48) | ALDH1A1LMNA | |
| SCHEMBL31230009 | 0.70 | MAPK1 (0.41) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL25626407 | 0.70 | MAPK1 (0.41) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL30677386 | 0.67 | MAPK1 (0.34) | MAPK1 | |
| SCHEMBL25267720 | 0.66 | CLK1 (0.38) | GCGRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL28380264 | 0.63 | MAPK1 (0.48) | CCNT1CDK9GSK3BMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118946360-A | Bicyclic heteroarenes and methods of use thereof | 奇尼塔公司 | 2024-11-12 | — | — | CN | disclosed |
| US-20230271965-A1 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | YUMANITY THERAPEUTICS, INC. | 2023-08-31 | — | — | US | disclosed |
| US-20230271965-A1 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | YUMANITY THERAPEUTICS, INC. | 2023-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271965-A1 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | NLN, GRIN2C, BCHE | GCGR 4739/4885MAPK13 4435/4885MAPK12 4602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.