SCHEMBL25263286

SCHEMBL25263286

O=C(OCc1ccccc1)c1cc2cc(CBr)ccc2s1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 7/20 0.49
CLK1 P49759 4/20 0.46
DYRK1A Q13627 2/20 0.46
SLC6A2 P23975 1/20 0.44
SLC6A3 Q01959 1/20 0.44
KMT2A Q03164 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
TSHR P16473 1/20 0.44
DYRK1B Q9Y463 1/20 0.43
F9 P00740 2/20 0.42
F10 P00742 2/20 0.42
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31232895 1.00 HDAC1 (0.49) HDAC1CLK1DYRK1ASLC6A2SLC6A3
SCHEMBL22468777 0.86 LMNA (0.50) HDAC1CLK1DYRK1ASLC6A2SLC6A3
SCHEMBL29570549 0.86 LMNA (0.50) HDAC1CLK1DYRK1ASLC6A2SLC6A3
SCHEMBL29065456 0.84 BCL2L1 (0.58) HDAC1DYRK1ASLC6A2SLC6A3KMT2A
SCHEMBL31232887 0.83 CLK1 (0.46) HDAC1CLK1DYRK1ASLC6A2SLC6A3
SCHEMBL22468637 0.83 TDP1 (0.45) HDAC1CLK1DYRK1ASLC6A2SLC6A3
SCHEMBL17149292 0.83 CLK1 (0.46) HDAC1CLK1DYRK1ASLC6A2SLC6A3
SCHEMBL9176841 0.83 CYP4F2 (0.51) HDAC1CLK1DYRK1ATDP1DYRK1B
SCHEMBL26298420 0.81 HDAC1 (0.44) HDAC1CLK1DYRK1ASLC6A2SLC6A3
SCHEMBL15698906 0.80 SLC6A2 (0.46) HDAC1CLK1DYRK1ASLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260015373-A1 STAT6 MODULATORS AND USES THEREOF RECLUDIX PHARMA INC (US) 2026-01-15 US disclosed
US-20250215030-A1 STAT MODULATORS AND USES THEREOF RECLUDIX PHARMA, INC. 2025-07-03 US disclosed
US-20250215029-A1 STAT MODULATORS AND USES THEREOF RECLUDIX PHARMA, INC. 2025-07-03 US disclosed
US-20250179103-A1 6-OXODECAHYDROPYRROLO[1,2-A][1,5]DIAZOCINE AND 6-OXODECAHYDRO-4H-PYRROLO[2,1-D][1,5]THIAZOCINE DERIVATIVES AS STAT3 AND STAT6 MODULATORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS RECLUDIX PHARMA, INC. 2025-06-05 US disclosed
EP-4499656-A1 STAT MODULATORS AND USES THEREOF Recludix Pharma, Inc. (US) 2025-02-05 EP disclosed
EP-4463459-A1 STAT MODULATORS AND USES THEREOF Recludix Pharma, Inc. (US) 2024-11-20 EP disclosed
WO-2023192960-A1 STAT MODULATORS AND USES THEREOF RECLUDIX PHARMA, INC. (US) 2023-10-05 WO disclosed
WO-2023164680-A1 6-OXODECAHYDROPYRROLO[1,2-A][1,5]DIAZOCINE AND 6-OXODECAHYDRO-4H-PYRROLO[2,1-D][1,5]THIAZOCINE DERIVATIVES AS STAT3 AND STAT6 MODULATORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS RECLUDIX PHARMA, INC. (US) 2023-08-31 WO disclosed
WO-2023133336-A1 STAT MODULATORS AND USES THEREOF RECLUDIX PHARMA, INC. (US) 2023-07-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179103-A1 6-OXODECAHYDROPYRROLO[1,2-A][1,5]DIAZOCINE AND 6-OXODECAHYDRO-4H-PYRROLO[2,1-D][1,5]THIAZOCINE DERIVATIVES AS STAT3 AND STAT6 MODULATORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS STAT6, STAT3, STAT1 HDAC1 168/4885CLK1 3404/4885DYRK1A 909/4885
US-20250215030-A1 STAT MODULATORS AND USES THEREOF STAT6, STAT3, STAT5A HDAC1 227/4885CLK1 2193/4885DYRK1A 842/4885
US-20260015373-A1 STAT6 MODULATORS AND USES THEREOF STAT6, STAT5A, STAT3 HDAC1 136/4885CLK1 1585/4885DYRK1A 2705/4885
US-20250215029-A1 STAT MODULATORS AND USES THEREOF STAT6, STAT3, STAT5A HDAC1 159/4885CLK1 2081/4885DYRK1A 955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.